Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Outcomes relating to fatigue and EDS will be collected weekly throughout the study. Other outcomes including general health, depression, and cognitive function will be collected at the start of each period, 4 weeks into each period, and again at the end of each period. It is hypothesized that participants taking Modafinil will report significantly less fatigue and EDS, report significantly better general health and depression scores, and perform significantly better on tests of cognitive performance in comparison to participants taking placebo.
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Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury - PMC
Last Update Posted : June 14, I have heard this from other TBI patients but I don't know why it is or if there are any studies about it. I had taken Provigil before my TBI, prescribed at mg, 1x a day. I was uncomfortable with that dose after my TBI and can only tolerate mg 1x a day, with breaks every other day or so, otherwise it now messes up my sleep schedule. Almost a Ans after my TBI, I Bain still struggling with getting back Provigio a normal daily rhythm of activity and rest.
I find that at best, I can stay more or less "on-task" for maybe 1 or 2 hours max. The effort to focus my thoughts and attention wears me out. I get extremely fatigued and sleepy.
The Ups and Downs of Changing Medications After Brain Injury | BrainLine
It would be Pfovigil if modafinil and armodafinil were also recognized as a cognitive and energy aid for post-TBI patients, since most insurances don't cover it for anything other than narcolepsy. I began taking nuvigil about three years post-TBI. To minimize side effects my dr started at a low dose twice a day and then gradually increased to the max 2x daily.
The effect was immediate --I could see in 3-d and my attention span no longer stopped at 2 minutes. The neurochemical underprint of this network is modulated by a combined input from cortical and subcortical catecholamine systems.
The Ups and Downs of Changing Medications After Brain Injury
The proposed mechanism of actions of modafinil Braun related to its ability to inhibit the NE and DA transporters. In addition, modafinil indirectly effects extracellular levels of serotonin, glutamate, orexin, histamine, and gamma-aminobutyric acid.
No funding was received for the preparation of this letter. Innov Clin Neurosci. Oleg V. TcheremissineMD and James C. RachalMD. Author information Copyright and License information Disclaimer. Corresponding author. Address for correspondence.
Tcheremissine, MD; Email: gro. Disclosure: The authors have no conflicts of interest relevant to the content of this article. Matrix Medical Communications.
All rights reserved. This article has been cited by other articles in PMC. With regard, Oleg V.
Although anecdotal reports suggest that Modafinil (Provigil) is helpful in treating fatigue in TBI. buymodafinilntx.com › author › brian-greenwald › ups-and-downs-changing-.