Arms and Interventions.Modafinil appears to be a drug with promise as an augmenter of antidepressants, especially in patients with residual tiredness or fatigue. Among the symptoms common with depression are energy loss/fatigue and anxiety. Modafinil has a novel mechanism of action and may have antidepressant properties.
Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Exclusion Criteria: Treatment refractory depression Serious or unstable medical condition.
Pregnancy Primary diagnosis of another Axis I or II disorder Alcohol or substance abuse or dependence within the past Provihil months.
Modafinil augmentation of antidepressant treatment in depression
Contacts and Locations. Information from the National Library of Medicine To Provugil more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. Major Depression Mental Health.
Provigil: Side effects, dosage, uses, and more
Drug: Provigil. Phase 4. Conclusion: Modafinil appears to be a drug with promise as an augmenter of antidepressants, especially in patients with residual tiredness or fatigue. It is a particularly attractive alternative to other stimulants because of its low abuse potential and Schedule IV status.
Abstract Background: Despite a relative lack of controlled data, stimulants are often used to augment antidepressant treatment in patients who have had only a partial response to first-line therapy. Thomas Provigil Treat Depression. Modafanil is a nonamphetamine "wake-promoting agent," and is a popular and well-tolerated treatment for the sleepiness associated with narcolepsy. Its mechanism of action is not well understood, but it may increase dopaminergic signaling or the activity of wake-promoting histamine neurons in the tuberomammillary nucleus.
This small, prospective, open-label, uncontrolled study enrolled twenty patients, sixteen of whom completed the study. All enrollees were receiving ongoing SSRI treatment for major depressive disorder and had experienced sedating side effects as a consequence of ongoing antidepressant therapy.
These patients were given Provigil modafinil once-daily, and Provjgil symptoms were assessed at baseline and Provigil Treat Depression weekly for 3 weeks. Dosage ranged from 50 mg to mg, depending on physician discretion and patient tolerability.
User Reviews for Modafinil to treat Depression Modafinil has an average rating of out of 10 from a total of 61 ratings for the treatment of Depression. Provigil in Conjunction With SSRIs for the Treatment of Mild or Moderate Depression With Attendant Symptoms of Sleepiness and Fatigue.