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Active Ingredients Provigil

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However, if you take it with food, Provigil might take slightly longer to start working. Provigil tablets should not be crushed or split. Although Provigil is a stimulant, its chemical makeup is different from the makeup of other stimulants, such as amphetamines.

This includes Provigil. For instance, the National Collegiate Athletic Association lists stimulants such as Provigil as prohibited during sports. Provigil can interact with several other medications. It can also interact with certain supplements as well as certain foods. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects. Below is a list of medications that can interact with Provigil.

This list does not contain all drugs that may interact with Provigil. Before taking Provigil, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Several medications can lessen the activity of an enzyme called cytochrome P 3A4 in your body. Taking these drugs with Provigil can cause your body to get rid of Provigil more slowly. This can cause more Provigil side effects. Provigil can increase the activity of an enzyme called cytochrome P 3A4 in your body. This can cause your body to get rid of certain medications more quickly.

As a result, these medications may become less effective. Provigil can reduce the activity of enzymes called cytochrome P 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.

Many other medications may be affected when taken with Provigil. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions. Taking Provigil with monoamine oxidase inhibitors MAOIs might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature.

Provigil should not be taken within 14 days of using an MAOI. Taking Provigil with warfarin Coumadin, Jantoven may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.

Provigil may interact with certain supplements or herbal products you may be taking. Examples of these include:. Taking Provigil with marijuana might change how marijuana affects you. Provigil alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This Active Ingredients Provigil increase or decrease the effects and side effects of marijuana.

Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Provigil might change how your body handles the drug. This could increase the amount of Provigil in your body and increase your risk of side effects.

Caffeine in foods and beverages might add to the stimulant effects of Provigil. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others. Alcohol can make you feel tired and sleepy. This can decrease the effects of Provigil, which is typically used to help you feel less tired and sleepy. Some people who take Provigil can have changes in mood or thinking that makes them feel more focused and more confident.

Although not common, some people may also experience feelings of euphoria. 60 Minutes Provigil effect can lead to Active Ingredients Provigil or abuse of Provigil for nonmedical uses.

Abuse or misuse is more likely to occur in people who have abused alcohol or drugs in the past. Other drugs are available that can treat your condition. Some may be better suited for you than others. Examples of other medications see more can be used to decrease daytime sleepiness in people with narcolepsy, sleep apnea, or shift work sleep disorder include:.

You may wonder how Provigil compares to certain drugs such as Nuvigil. Provigil and Nuvigil are very similar medications. That means that their chemical makeup is virtually identical, but the chemicals are arranged slightly differently. Provigil and Nuvigil are considered first-choice medication options for decreasing sleepiness in people with narcolepsy, sleep apnea, and shift work sleep disorder. Active Ingredients Provigil said, an analysis of clinical studies indicates that Provigil and Nuvigil might work about equally well for reducing sleepiness for people with Active Ingredients Provigil apnea.

Provigil and Nuvigil are both brand-name drugs. The generic name of Nuvigil is armodafinil. Generic drugs are typically less expensive than brand-name drugs. The brand and generic versions of Provigil appear to be more expensive than the brand and generic versions of Nuvigil. Whichever drug you take, the amount you pay will depend on your health insurance plan. You may wonder how Provigil compares to certain drugs such as Vyvanse.

Provigil and Vyvanse lisdexamfetamine are both stimulant medications, but they affect the brain in slightly different ways.

Provigil increases wakefulness and alertness. Vyvanse can cause wakefulness and, in people with attention deficit hyperactivity disorder ADHDcan also produce feelings of calm and focus. Provigil is FDA-approved for treating daytime sleepiness caused by narcolepsy, sleep apnea, and shift work sleep disorder. Vyvanse is used off-label for these uses. Provigil is used off-label for these uses. Vyvanse is Active Ingredients Provigil as a capsule and Ingerdients chewable tablet, each of which is taken once daily.

Provigil and Vyvanse are both stimulant medications. As a result, they have several similar side effects. For the treatment of ADHD, these medications have not been directly compared in clinical studies.

However, according to an analysis of clinical Acitve, Vyvanse appears to be more effective than Provigil for treating ADHD in adults.

Active Ingredients Provigil medications have also not been directly compared in clinical studies looking at decreasing daytime sleepiness in people with narcolepsy or other disorders. Provigil and Vyvanse are brand-name drugs. Provigil is also available in a generic form called modafinil, but Vyvanse is not available as a generic. Provigil costs more than Vyvanse. However, the generic version of Provigil costs less than Vyvanse.

Provigil (Modafinil) Oral: Uses, Side Effects, Dosages

The actual amount you pay will depend on Aftive health insurance plan. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain. These actions may result in stimulation of brain activities, which Active Ingredients Provigil make you feel less tired.

Provigil begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working. Some research in animals has shown negative effects to a fetus when the mother takes this drug.

Slowed growth of the fetus and spontaneous abortion have occurred in women who took Provigil. This medication should only be used during pregnancy if the benefit justifies the potential risk. If you do take Provigil while pregnant, you can sign up for a registry that will help gather information about your experience. Pregnancy exposure registries help healthcare professionals learn more about how certain drugs affect women and their pregnancies.

To sign up, call You may need to decide whether to stop breastfeeding or stop taking this medication. For most people, it usually takes 30 to 60 minutes to start working. If you take Provigil with food, it Ingreddients take slightly longer. Modalert is another name for Provigil. This form of Provigil is sold in countries outside of North America. For most people who take Provigil as prescribed by their doctor, it continues to work Ingedients when taken for long periods of Active Ingredients Provigil.

They may Ingrediens to increase your dosage or consider Achive different medication. If you think you or your child has taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at or through their online tool.

But if your symptoms are severe, call or go to the nearest emergency room https://buymodafinilntx.com/3-provigil-and-fertility-hyf.php away. When Provigil is dispensed from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically one year from the date the medication was dispensed.

However, an FDA study showed Active Ingredients Provigil many medications may still be good beyond the expiration date listed on the Active Ingredients Provigil. How long a medication remains good can depend on many factors, including how and where the medication is stored. Provigil should be stored at room temperature. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it.

Before taking Provigil, talk with your doctor about your health history. Provigil may not be right for you if you have certain medical conditions.

Active Ingredients Provigil include:. Provigil is a stimulant with Active Ingredients Provigil dissimilar compared to other central nervous stimulants such as amphetamine or methylphenidate.

Provigil does not have alpha-adrenergic effects, but the alpha-adrenergic antagonist prazosin can decrease the wakefulness effects of Provigil. Provigil Provigill reuptake does not have dopamine receptor agonist activity. Dopamine antagonists do not block wakefulness from Provigil. Animal studies show that Provigil increases glutaminergic activity in the thalamus and Ingredents.

Provigil is readily absorbed when taken orally and reaches peak plasma concentration within 2 to 4 hours. Peak levels may be delayed by about an hour when the drug is taken with food. Provigil is Active Ingredients Provigil eliminated via the liver. Provigil induces cytochrome P 3A4 and induces its own metabolism through this route. Provigil is Active Ingredients Provigil in people who have had a hypersensitivity reaction to Provigil or Nuvigil armodafinil in the past.

Provigil is a Schedule IV controlled substance. Studies show that Provigil has the potential Like Provigil Stimulant cause euphoric effects and feelings consistent with other stimulants, including methylphenidate.

People with a history of alcohol or drug abuse may have a higher risk of abusing Provigil. Disclaimer : MedicalNewsToday has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date.

However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Patients should be observed for signs of misuse or abuse e.

The abuse potential of modafinil, and mg was assessed relative to methylphenidate 45 and 90 mg in an inpatient study in individuals experienced with drugs of abuse. Results from this clinical study demonstrated that modafinil produced psychoactive and euphoric effects and feelings consistent with other scheduled CNS stimulants methylphenidate.

In one placebo-controlled clinical trial, the effects of modafinil withdrawal were monitored following 9 weeks of modafinil use. There were no reported withdrawal symptoms with modafinil during 14 days of observation, although sleepiness returned in narcoleptic patients. In addition, several intentional acute overdoses occurred; the two largest being mg and mg taken by two subjects participating in foreign depression studies.

None of these study subjects experienced any unexpected Proviigil life-threatening effects. Adverse reactions that were reported at these doses included excitation or agitation, insomnia, and slight or moderate elevations in hemodynamic parameters.

Other observed high-dose effects in clinical studies have included anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, diarrhea, and decreased prothrombin time. From postmarketing experience, there have been reports of fatal overdoses involving modafinil alone or in combination with other drugs. Symptoms most often accompanying PROVIGIL overdose, alone or in combination with other drugs have included insomnia; central nervous system symptoms such as restlessness, disorientation, confusion, agitation, anxiety, excitation, and hallucination; digestive changes such as nausea and diarrhea; and cardiovascular changes such as tachycardia, bradycardia, hypertension, and chest pain.

The child remained stable. The symptoms associated with overdose in children were similar to those observed in adults. Such overdoses should be managed with primarily supportive care, Ingrediets cardiovascular monitoring. Modafinil is a racemic compound. Modafinil is a white to off-white, crystalline powder that is practically insoluble in water and cyclohexane. It is sparingly to slightly soluble in methanol and acetone.

PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate, read article stearate, microcrystalline cellulose, povidone, and pregelatinized starch. The mechanism s through which modafinil promotes wakefulness is unknown.

Modafinil Active Ingredients Provigil wake-promoting actions similar to Active Ingredients Provigil agents including amphetamine and methylphenidate, although the pharmacologic profile is not identical to that of the sympathomimetic amines. Modafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in Atcive, modafinil binds to the dopamine transporter and inhibits dopamine reuptake.

Provigil (Modafinil) - Oral

Provigill activity has been associated in vivo with increased extracellular dopamine levels in some brain regions of animals. In genetically engineered mice lacking the dopamine transporter DATmodafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent.

However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the dopamine receptor antagonist haloperidol in rats.

What are the ingredients in PROVIGIL? Active Ingredient. Modafinil, sold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea.

In addition, alpha-methyl-p-tyrosine, a dopamine synthesis inhibitor, blocks the action of amphetamine, but does not block locomotor activity induced by modafinil. In the cat, equal wakefulness-promoting doses of methylphenidate Active Ingredients Provigil amphetamine increased neuronal activation throughout the brain. Modafinil at an equivalent wakefulness-promoting dose selectively and prominently increased neuronal activation in more discrete regions of the brain.

The relationship of this finding in cats to the effects of modafinil in humans is unknown. In addition to its wake-promoting effects and ability to increase locomotor activity in animals, modafinil produces psychoactive and euphoric effects, alterations in mood, perception, thinking, and feelings typical of other CNS stimulants in humans.

Modafinil has reinforcing properties, as evidenced by its self-administration in monkeys previously trained to self-administer cocaine; modafinil was also partially discriminated as stimulant-like.

The optical enantiomers of modafinil have similar pharmacological actions in animals. Two major metabolites of modafinil, modafinil acid and modafinil sulfone, do not appear to contribute to the CNS-activating properties of modafinil. Modafinil is a racemic compound, whose enantiomers have different pharmacokinetics e. The enantiomers do not interconvert. At steady state, total exposure to R-modafinil is approximately three times that for S-modafinil.

The effective elimination half-life of modafinil after multiple doses is about 15 hours. Apparent steady states of total modafinil and R-modafinil are reached after days of dosing.

Food has no effect on overall PROVIGIL bioavailability; however, time to reach peak concentration t max may be delayed by approximately one hour if taken with food.

Urine alkalinization has no effect on the elimination of modafinil. Metabolism occurs through Active Ingredients Provigil deamidation, S-oxidation, aromatic Active Ingredients Provigil hydroxylation, and glucuronide conjugation. The largest fraction of the drug in urine was modafinil acid, but at least six other metabolites were present in lower concentrations. Only two metabolites reach appreciable concentrations in plasma, i. In preclinical models, modafinil acid, modafinil sulfone, 2-[ diphenylmethyl sulfonyl]acetic acid and 4-hydroxy modafinil, were inactive or did not appear to mediate the arousal effects of modafinil.

In adults, decreases in trough levels of modafinil have sometimes been observed after multiple weeks такую Provigil Makes Me Angry моему dosing, suggesting auto-induction, but the magnitude of the decreases and the inconsistency of their occurrence suggest that their clinical significance is minimal.

Significant accumulation of modafinil sulfone has been observed after multiple doses due to its long elimination half-life of 40 hours. Due to potential effects from the multiple concomitant medications with which most of the patients were being treated, the apparent difference in modafinil pharmacokinetics may not be attributable solely to the effects of aging.

However, the results suggest that the clearance of modafinil may be reduced in the elderly [see Dosage and Administration 2. The pharmacokinetics and metabolism of modafinil were examined in patients with cirrhosis of the liver 6 men and 3 women. Clinically 8 of 9 patients were icteric and all had ascites.

In vitro data also demonstrated that modafinil produced an apparent concentration-related suppression of expression of CYP2C9 activity. Other CYP activities did not appear to be affected by modafinil. The existence of multiple pathways for modafinil metabolism, as well as the fact that a non-CYP-related pathway is the most rapid in metabolizing modafinil, suggest that there is a low probability of substantive effects on Provigil Iherb overall pharmacokinetic profile of PROVIGIL due to CYP inhibition by concomitant medications.

There was no evidence of tumorigenesis associated with modafinil administration in these see more. However, the mouse study was inadequate because the high dose was not a maximum tolerated dose MTD. Modafinil was negative in a series of in vitro i.

The Active Ingredients Provigil for narcolepsy Active Ingredients Provigil either: 1 recurrent daytime naps or lapses into sleep that occur almost daily for at least three months, plus sudden bilateral loss of postural muscle tone in association with intense emotion cataplexy ; or 2 a complaint of excessive sleepiness or sudden muscle weakness with associated features: sleep paralysis, hypnagogic hallucinations, automatic behaviors, disrupted major sleep episode; and polysomnography demonstrating one of the following: sleep latency less than 10 minutes or rapid eye movement REM sleep latency less than 20 minutes.

For entry into these studies, all patients were required to have objectively documented excessive daytime sleepiness, via a Multiple Sleep Latency Test MSLT with two or more sleep onset REM periods and the absence of any other clinically significant active medical or psychiatric disorder.

For each test session, the subject was told to lie quietly and attempt to sleep. Each test session was terminated after 20 minutes if no sleep occurred or 15 minutes after sleep onset.

For a successful trial, both measures had to show statistically significant improvement. The MWT measures latency in minutes to sleep onset averaged over 4 test sessions at 2 Active Ingredients Provigil intervals following nocturnal polysomnography.

For each test session, the subject was asked to attempt to remain awake without using extraordinary measures. Each Active Ingredients Provigil session was terminated after 20 minutes if no sleep occurred or 10 minutes after sleep onset.

Patients were rated by evaluators who had no access to any data about the patients other than a measure of their baseline severity.

Modafinil - Wikipedia

Evaluators were not given Active Ingredients Provigil specific guidance about the criteria they were to apply when rating patients. Both studies demonstrated improvement in objective and subjective measures of excessive daytime sleepiness for both the mg and mg doses compared to placebo. The criteria include either: 1 excessive sleepiness or insomnia, plus frequent episodes of impaired breathing during sleep, and associated features such as loud snoring, Provigil Pills Like headaches and dry mouth upon awakening; or 2 excessive sleepiness or insomnia and polysomnography demonstrating one of the following: more than five obstructive apneas, each greater than 10 seconds in duration, per hour of sleep and one or more of the following: frequent arousals from sleep associated with the apneas, bradytachycardia, and Active Ingredients Provigil oxygen desaturation in association with the apneas.

CPAP use continued throughout the study. The primary measure of effectiveness was the change from baseline on the ESS at final visit. At week 4, the ESS was reduced by 4. Active Ingredients Provigil patients met the criteria for chronic SWD.

The criteria include: 1 either, a a primary complaint of excessive sleepiness or insomnia which is temporally associated with a work period usually night work that occurs during the habitual sleep phase, or b polysomnography and the MSLT demonstrate loss of a normal sleep-wake pattern i. It should be noted that not all patients with a complaint of sleepiness who are also engaged in shift work meet the criteria for the diagnosis of SWD. In the clinical trial, only patients who were symptomatic for at least 3 months were enrolled.

Advise patients to stop taking PROVIGIL and to notify their physician right away if they develop a rash, hives, mouth sores, blisters, peeling skin, trouble swallowing or breathing, or a related allergic phenomenon. Advise patients not to alter their previous behavior with regard to potentially dangerous activities e.

Inform patients that it may be critical that they continue to take their previously prescribed treatments e. Advise patients to stop taking PROVIGIL and contact their physician right away if they experience chest pain, rash, depression, anxiety, or signs of psychosis or mania. Advise patients to notify their physician if they become pregnant or intend to become pregnant during therapy.

Provigil (modafinil)

Caution patients regarding the potential increased risk of pregnancy when using steroidal contraceptives including depot or implantable contraceptives with PROVIGIL and for one month after discontinuation of therapy.

There may be new information. This information does not take the place of talking with your doctor about your medical condition or treatment. PROVIGIL may cause serious side effects including a serious rash or a serious allergic reaction that may affect Ingredints Active Ingredients Provigil your body such as your liver or blood cells.

Any of these may need to be treated in a hospital and may be life-threatening. If you have a severe Ingredienhs with PROVIGIL, stopping the medicine may not keep the rash from becoming life-threatening or causing you to be permanently disabled or disfigured. PROVIGIL is a prescription medicine used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders:.

Follow your doctor's advice about good sleep habits and using other treatments. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, Active Ingredients Provigil street drugs.

Tell your doctor about all of your medical conditions including, if you:. Tell your doctor about all the medicines you takeincluding prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them and show it to your doctor and Active Ingredients Provigil when you get a new Active Ingredients Provigil.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. Medicines are sometimes prescribed for purposes other than those listed in Ingredienhs Medication Guide.

It may harm them read more it is against the law. If you would Ingredisnts more information, talk with Ihgredients doctor. For more information, call Inactive Ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone, and magnesium stearate.

Rx only teva. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. DailyMed will deliver this notification to Acfive desktop, Web browser, or e-mail depending on the RSS Reader you select to use.

Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImagewe no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify Inngredients filter out images that do not match the information provided in the Ingedients labels. View Package Photos. Drug Label Info. NDC National Drug Code - Each drug product is assigned this unique number which can be found on Provigjl drug's outer packaging.

Approval: The following serious adverse reactions are described Active Ingredients Provigil in the labeling: Serious Rash, including Stevens-Johnson Syndrome [see Warnings and Precautions 5. Table 1. Cardiovascular: Stroke Hematologic: agranulocytosis Psychiatric disorders: psychomotor hyperactivity.

The chemical structure is:.

PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: croscarmellose sodium, lactose monohydrate. PROVIGIL tablets contain mg or mg of modafinil and the following inactive ingredients: lactose, microcrystalline cellulose.

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