Its mechanism of action is not well understood, but it may increase dopaminergic signaling or the activity of wake-promoting histamine neurons in the tuberomammillary nucleus.
Modafinil reduces depression's severity when taken with antidepressants -- ScienceDaily
This small, prospective, open-label, uncontrolled study enrolled Derpession patients, sixteen of whom completed the study. All enrollees were receiving ongoing SSRI treatment for major depressive disorder and had experienced sedating side effects as a consequence of ongoing antidepressant therapy.
These patients were https://buymodafinilntx.com/3-nuvigil-versus-provigil-side-effects-sutu.php Provigil modafinil once-daily, and their symptoms were assessed at baseline and then weekly for 3 weeks. Dosage ranged from 50 mg to mg, depending on physician discretion and patient tolerability. The study advises caution when combining Provigil modafinil with other drugs.
Modafinil augmentation of antidepressant treatment in depression
The drug is hepatically metabolized and induces several cytochrome P enzymes, thus decreasing the effectiveness of oral contraceptives and perhaps other medications that are metabolized by cytochrome P and cytochrome CYP2C19 pathways.
The researchers acknowledge that the study is limited by its small sample size, lack of control group, and open-label methodology, but they say their positive findings warrant further, systematic study. Jeff Minerd is a freelance medical and science writer based in Rochester, NY. Source Reference: Schwartz TL, et al. In a single outpatient clinic, data were systematically collected on all patients including those who began modafinil treatment for major depression.
This clinician C. A Treatmsnt chart review identified 45 patients whose major depression was treated with modafinil over a 9-month period.
The mean dose of modafinil was For these 45 patients, all four rating scales showed significant improvement following Fog weeks and following 3 months of modafinil treatment.
Modafinil appears to be a drug with promise as an augmenter of antidepressants, especially in patients with residual tiredness or fatigue. Major depression is often refractory to antidepressants, and it is important to explore alternative medication treatments. Among the symptoms common with.