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Provigil Motivation

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Posted by Mar on 2022-05-31

Neurosci Lett : 20— Modafinil prevents glutamate cytotoxicity in cultured cortical neurons. Neuroreport 9 : — Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity. Brain Res : — Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization Provigil Motivation noradrenergic receptors and axons.

Cereb Cortex 8 : — Arnsten AF Adrenergic targets for the treatment of cognitive deficits in schizophrenia. Provigil Motivation : 25— Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine.

Neurobiol Aging 14 : — Alpha-2 adrenergic agonists decrease distractibility Motivatiob aged monkeys performing the delayed response task. Psychopharmacology : — Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science New York, NY : — Activity of norepinephrine-containing Provigio coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle.

J Neurosci 1 : — An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Ann Rev Neurosci 28 : — Neuromodulation and cognitive performance: recent studies of noradrenergic locus ceruleus neurons in behaving monkeys. Conditioned Motivztion of monkey locus coeruleus neurons anticipate acquisition Pfovigil discriminative behavior in a vigilance task. Neuroscience 80 : — Locus coeruleus neurons in monkey are selectively activated by attended cues Provjgil a vigilance task.

J Neurosci 14 : — Role of the locus coeruleus in emotional activation. Prog Brain Res : — Ballon JS, Feifel D A systematic review of modafinil: potential clinical Motlvation and mechanisms of action. J Clin Psychiatry 67 : — Effects of modafinil on Provigil Motivation and Procigil performance.

Hum Psychopharmacol 19 : — Beatty J a. Phasic not tonic pupillary responses Provigli with auditory Motivaation performance. Psychophysiology 19 : — Beatty J b. Task-evoked pupillary responses, processing load, Motivxtion the structure of processing resources. Psychol Bull 91 : — First evidence of Provigil Motivation delay-dependent working memory-enhancing effect of modafinil in mice. Neuroreport 12 : — Improvement Motiavtion learning processes following chronic systemic administration of modafinil in mice.

Pharmacol Biochem Behav : — Enhancement of learning processes following an acute modafinil injection in mice. Pharmacol Biochem Behav 76 : — Use of modafinil in the treatment of narcolepsy: a long term follow-up study.

Provigil Motivation Clin 26 : 60— Pediatrics : e—e PubMed Article Google Scholar. Modafinil: a double-blind multicentric study. Sleep 17 : S—S Acetylcholine, histamine, and cognition: two sides of the same coin. Learn Mem 11 : 1—8. Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function.

Biol Psychiatry 46 : — Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology Mtoivation : — Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques.

Life Sci 19 : — Reserpine impairs spatial working memory performance in monkeys: reversal by the alpha 2-adrenergic agonist clonidine. Blockade of the noradrenaline carrier Provigil Motivation extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals.

J Neurochem 55 : — Distinctive effects of modafinil and d-amphetamine on Pgovigil homeostatic and circadian modulation of the human waking EEG.

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 : — Immunocytochemical localization of the dopamine transporter in human brain. J Comp Neurol : 38— Dopamine activates noradrenergic receptors in the preoptic area. J Neurosci 22 : — Crochet S, Sakai K Dopaminergic modulation of behavioral states in mesopontine tegmentum: a reverse microdialysis study in freely moving cats. Sleep 26 : — Modafinil for excessive sleepiness associated with shift-work sleep disorder.

N Eng J Med : — A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology Motivatiin : — Dagan Y, Doljansky JT Cognitive performance during sustained wakefulness: a low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. Chronobiol Provigil Motivation 23 Provigil Motivation — Sexual dimorphism of the catechol-O-methyltransferase Mtoivation in narcolepsy is associated with response to modafinil.

Pharmacogenomics J 2 : 65— Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: in vivo voltammetry studies. Neuropharmacology 33 : — A prospective Provigil Ask A Patient of modafinil as an Provigil Motivation treatment of major depression.

J Clin Psychopharmacol 24 : 87— Influence of modafinil on somatosensory input processing in the human brain-stem. Clin Neurophysiol : — Dequardo JR Modafinil-associated clozapine toxicity.

Am J Psychiatry : — Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol Psychiatry 6 : — Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex.

J Neurochem 88 : — Mirtazapine-induced corelease of dopamine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. Eur J Pharmacol : — Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex.

J Neurochem 92 : — Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology : 79— Dissociation in prefrontal cortex of affective and attentional shifts. Nature : 69— Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Curr Med Res Opin Provigil Motivation : — Durstewitz D, Seamans JK The computational role of dopamine D1 receptors in working memory.

Neural Netw 15 : — Article PubMed Google Scholar. Provigil Motivation possibe alpha-adrenergic mechanism for drug CRL -induced hyperactivity. Eur J Pharmacol 59 : — Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol : 49— Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.

Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J Pharmacol Exp Ther : — Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil. J Sleep Res 8 : 85— Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine.

Neuroscience 87 : — Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil. Neurosci Lett : 95— Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial.

Br J Psychiatry : — A multicenter, placebo-controlled study of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness. J Clin Psychiatry 66 : 85— The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus.

Neuroreport 8 : — Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol Psychiatry 42 : — The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission.

The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. Neuropsychopharmacology 20 : — Modafinil enhances the increase Provigil Motivation extracellular serotonin levels induced by the antidepressant drugs fluoxetine and imipramine: a dual probe microdialysis study in awake rat.

Synapse New York, NY 55 : — Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology 39 : — Differential enhancement of Provigil Motivation serotonin levels in distinct brain regions of the awake rat by modafinil: possible relevance for wakefulness and depression.

J Neurosci Res 68 : — Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs.

The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor. Neurosci Lett : 5—8. Effect of modafinil on cerebral blood flow of anaesthetised rats. Comparison with amphetamine. Exp Brain Res : — Evidence for a protective action of the vigilance promoting drug modafinil on the MPTP-induced degeneration of the nigrostriatal dopamine neurons in the black mouse: an immunocytochemical Provigil Motivation biochemical analysis.

Exp Brain Res 88 : — Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study. Sleep 27 : 19— Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits. Inhibitory effects of trace amines on rat midbrain dopaminergic neurons.

Neuropharmacology 46 : — Cognitive performance following modafinil versus placebo in sleep-deprived emergency physicians: a double-blind Motovation crossover study. Acad Emerg Med 13 : — Evaluation of Provigil Motivation cocaine-like discriminative stimulus effects and reinforcing effects of modafinil. Targeting the dopamine D1 receptor in schizophrenia: insights link cognitive dysfunction.

Psychopharmacology : 3— Haas H, Panula P The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev 4 : — The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy.

Modafinil Motifation disruptions in cognitive performance during simulated night-shift work. Neuropsychopharmacology 31 : — Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers.

J Clin Pharmacol 41 : — Steady-state pharmacokinetics and tolerability of modafinil administered go here or in combination with dextroamphetamine in healthy volunteers. J Clin Pharmacol 42 : — Awakening properties of modafinil: effect on nocturnal activity in Provigil Motivation Macaca mulatta after acute and repeated administration.

Psychopharmacology : 28— Alpha- and beta-adrenoceptors: from the gene to the clinic. Molecular biology and adrenoceptor subclassification. J Med Chem 38 : — Respir Med : — Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal Provigil Motivation autonomic functions in human volunteers.

Impact of modafinil on prefrontal executive function in schizophrenia.

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Modafinil increases histamine release in the anterior hypothalamus of rats. Jasinski DR An evaluation of the abuse potential of modafinil using methylphenidate as a reference. J Psychopharmacol 14 : 53— Loss of autoreceptor functions in mice lacking the dopamine transporter. Nat Neurosci 2 : — The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis.

Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors. Neuropharmacology 52 : — Effects of mammillary bodies and mediodorsal thalamic lesions on the acquisition and retention of a Provigil Motivation set in mice: paradoxical effect of the intersession interval. Motivatiln Brain Res 67 : 51— Noradrenergic innervation of monkey prefrontal cortex: a dopamine-beta-hydroxylase immunohistochemical study. J Comp Neurol : — Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys.

Neuropsychopharmacology 21 : — J Sleep Res 9 : 89— Potential brain neuronal targets for amphetamine- methylphenidate- and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat. Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy. Neurology 59 : — Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.

Modafinil and cocaine interactions. Am J Drug Alcohol Abuse 32 : — Dopamine decreases the calcium-activated afterhyperpolarization in hippocampal CA1 pyramidal cells. Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice. Behav Brain Res 44 : — Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 17 : — Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers.

Psychopharmacology : 76— Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of Provigil Motivation agents. J Psychopharmacol 14 : — Primate trace amine receptor 1 modulation by the dopamine transporter. Sleep Med 1 : — Modafinil improves attention, inhibitory control, and reaction time in healthy, middle-aged rats.

Pharmacol Biochem Behav 86 : — Dopamine uptake through the rPovigil transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.

Effects of modafinil on working memory processes in humans. D1 receptor in interneurons of macaque prefrontal cortex: distribution and subcellular localization. J Neurosci 18 : — Modafinil enhances extracellular Provigil Motivation of dopamine in the nucleus accumbens and increases wakefulness in rats. Behav Brain Res : — Modafinil: preclinical, clinical, and post-marketing surveillance—a review of abuse liability issues.

Ann Clin Psychiatry 16 : — P and treatment effect of modafinil on fatigue in multiple sclerosis. J Clin Neurosci 14 : Provigil Motivation Is psychosis exacerbated by modafinil? Arch Gen Psychiatry 59 : Motivvation The functional anatomy of verbal initiation and suppression using the Hayling Test. Neuropsychologia 35 : — The role of the dorsolateral prefrontal cortex: evidence from the effects of contextual constraint in a sentence completion task.

NeuroImage 16 : — Nishino Prpvigil Biol Psychiatry 54 : 87— Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy.

Oskooilar N A case of premature ventricular contractions with modafinil. Central histaminergic system and cognition. Neurosci Biobehav Rev 24 : — Effects of the vigilance promoting drug modafinil on the synthesis of GABA and check this out in slices of rat hypothalamus.

Modafinil-induced modulation of working memory and plasma corticosterone in chronically-stressed mice. Pharmacol Biochem Behav 83 : 1—8. A double-blind placebo-controlled trial of modafinil for negative symptoms in schizophrenia. Neuropsychopharmacology 30 Suppl 1 : S Google Scholar. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 4 : — Modafinil- amphetamine- and methylphenidate-induced hyperactivities in mice involve different mechanisms.

Article Google Scholar. The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers. Pharmacol Biochem Behav 77 : — Cognitive effects of modafinil in student volunteers may depend on IQ.

Pharmacol Biochem Behav 82 : — Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol 18 : — Does modafinil Provigil Motivation cognitive Proigil in young volunteers who are not sleep-deprived? J Clin Psychopharmacol 25 Provigil Motivation — Motivwtion S, Chandra Provigil Motivation Modafinil-induced irritability and aggression?

A report of 2 bipolar patients. Richer F, Beatty J Mltivation Contrasting effects of response uncertainty on Provigi, task-evoked pupillary response and reaction time. Psychophysiology 24 : — In vitro inhibition and induction of human hepatic cytochrome P enzymes by modafinil. Drug Metab Dispos 28 : — Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet 42 : — Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers.

Provigil Motivation of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther 71 : 46— Benefits of adjunct modafinil in an open-label, pilot Proviggil in patients with schizophrenia. Clin Neuropharmacol 27 : 38— Clin Ther 28 : — Modafinil in children with attention-deficit hyperactivity disorder.

Provigil Motivation Neurol 29 : — EEG-tomographic studies with LORETA on vigilance differences between narcolepsy patients and controls and subsequent double-blind, placebo-controlled studies with modafinil.

J Neurol : — Low-resolution brain electromagnetic tomography LORETA identifies brain regions linked to psychometric performance under modafinil in narcolepsy. Psychiatry Res : 69— Comparison of pramipexole and modafinil on arousal, autonomic, and endocrine functions in healthy volunteers. J Psychopharmacol 20 : — Longer auditory and visual P latencies in patients with narcolepsy. Clin Electroencephalogr 30 : 28— Visual P Provigil Motivation predicts treatment response to modafinil in patients with narcolepsy.

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Sawaguchi T Attenuation of delay-period Pgovigil of monkey prefrontal neurons by an alpha2-adrenergic Angry Provigil Makes Me during an oculomotor delayed-response task.

J Neurophysiol 80 : — D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science : — The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys Provvigil an oculomotor delayed-response task.

J Neurophysiol 71 : — Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20 : — Modafinil as adjunct therapy for daytime Motlvation in obstructive sleep apnea: a week, open-label study. Chest : — Effects of modafinil on wakefulness and executive function in patients with narcolepsy experiencing late-day Motication.

Clin Neuropharmacol 27 : 74— Determination of modafinil in plasma and urine by reversed phase high-performance liquid-chromatography. J Pharm Biomed Anal 37 : — The principal features and Provigil Motivation of dopamine modulation in the prefrontal cortex.

Prog Neurobiol 74 : 1— Cellular and subcellular localization of the dopamine transporter in rat cortex. Adv Pharmacol 42 : — Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients Motivatino with psychotropic medications.

J Mogivation Psychiatry 66 : — Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Sleep 18 : — Probigil mechanism of stimulant locomotor effect of modafinil in mice.

Eur Neuropsychopharmacol 5 : — The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine. Heterogeneous targets of dopamine synapses in monkey prefrontal cortex demonstrated by serial section electron microscopy: a laminar analysis using the silver-enhanced diaminobenzidine sulfide SEDS Mtoivation technique.

Cereb Cortex 3 : — D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines. Single-unit and polygraphic recordings associated with systemic or local pharmacology: a multi-purpose stereotaxic Motivahion for the Motivatioh, anaesthetic-free, and head-restrained rat.

J Neurosci Res 61 : 88— Modafinil modulates anterior cingulate function in chronic schizophrenia. Br J Psychiatry : 55— Role of brain alpha 1B-adrenoceptors in modafinil-induced behavioral activity. Synapse 46 : — Stress-induced subsensitivity to modafinil and its prevention by corticosteroids.

A randomized, double-blind, crossover trial of modafinil on mood. J Clin Psychopharmacol 27 : 76— His focus is on something more potent than coffee: ADHD and wakefulness disorder-drugs such as Adderall and modafinil. There is little dispute that these can give a minor cognitive boost to individuals with these conditions, and perhaps to the Mitivation more Provigil Motivation. Because of that, the ethical discussion about their off-label use normally centres on cheating and coercion.

Is it fair if some students use them to get better grades? Might their use by some employees coerce Provigil Motivation to take them as well, just to keep up? But Kjaersgaard is focused on another matter: What do we risk by using substances that enhance our enjoyment and interest in certain pursuits — say, a university major or career — which we would otherwise Motivatioon meaningless and alienating? Might we end up leading deeply inauthentic lives, using pharmaceutically-induced willpower to waft through a life that otherwise means nothing to us?

In other words, Kjaersgaard is concerned about the impact of these drugs on our moods and motivations, not cognition. This is because, despite repeated claims to the contrary, the evidence that these drugs enhance the cognitive abilities of off-label users is, Provigil Motivation best, mixed. In the case of drugs like Adderall and Ritalin, a survey of over 50 experiments testing their effects on cognition among healthy, young adults found a roughly even mixture of significant and null results, with reason to believe that many other null results go unreported.

The results from our study indicate that modafinil increases the subjective pleasure gained through behaviorally demanding situations without. Conclusions. These data support the hypothesis that modafinil increases motivation. Moreover, given the similarity of effects with GBR, the.

In the case of modafinil, which is often held as the more potent enhancer, little evidence exists that it has any significant cognitive effect on healthy participants. In fact, two recent studies found that it slows Provigil Motivation the response time of users in certain tasks and hinders creative thinking.

But these findings are difficult to reconcile with anecdotal reports from users who insist that, at least, Provigl about these drugs seems to make them work harder or study better.

What are we to make of these claims? What would normally illicit procrastination now interesting, enjoyable, entrancing even. For instance, a study looking at the effects of Click failed to find cognitive enhancement effects, but uncovered that users tended to believe their performance was enhanced compared to those given a placebo.

Taken together, it seems all we Provigil Motivation say with any confidence about so-called smart pills is that they act on our moods and dispositions in a way that makes us feel Insurance Denied Provigil to the task at hand.

They help us employ our otherwise standard cognitive capacities for prolonged periods and with Provigil Motivation sort of zeal we might feel after a very strong coffee. That is, they seem to work, in part at least, by boosting our motivation. Sometimes lacking motivation in life is symptomatic of Provigil Motivation deeper problem: a bad career choice, a university major that does not interest you, or a lifestyle that does Motkvation suit you.

Treating that alienation with a motivation enhancer, rather than re-evaluating the course of your life, seems like a bad idea. But what about situations where Motivatuon life choices are limited? In a response to Kjaersgaard, Cesar Palacios-Gonzalez and David Lawrence ask us to consider the hypothetical case of a single mother in the midst of an economic crisis who takes on an unfulfilling menial job as the only means to securing healthcare for her children.

Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors?

And in such cases, why not make the part that we have Provkgil and consciously sacrificed feel more enjoyable than Provigil Motivation actually is? In the case of the single mother or the myriad other similar circumstancesis it justified that the only way she can secure healthcare for her children is by taking up a deeply alienating job? Why strive for a better world when Provigil Motivation can artificially induce the enjoyment of the otherwise unenjoyable — and indeed, of Motivatoon unjust?

Are you a scientist who specializes in neuroscience, cognitive science, or psychology?

Conclusions: These data support the hypothesis that modafinil increases motivation. Moreover, given the similarity of effects with GBR, the. Background: Modafinil is prescribed for the treatment of narcolepsy. It has been postulated that modafinil might treat cognitive disruption.

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